Associated Data
Go to: Abstract The aim of this study was to explore the effects of Garcinia mangostana Papwr and Curcuma longa independently and synergistically in modulating oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models. Oxidative stress markers, glucose, and lipid fractions were measured in the sera. As anti-atherogenic agents MPE demonstrate Dyslipidemia Research Paper effect recorded higher level of HDL-C in http://pinsoftek.com/wp-content/custom/stamps/key-stage-essays.php animals, but ineefective as anti-dyslipidemic agent.
Curcumin was more effective in reducing LDL-C levels in obese rats.
Both extracts effectively reduced blood glucose. The present study demonstrated that MPE and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis. Subject terms: Biochemistry, Drug discovery Go to: Introduction Obesity is a complex metabolic disorder with multifactorial etiology.
Background
Obesity can lead to reduced quality of life due to numerous associated complications, including cardiovascular disease, diabetes, cancer, asthma, sleep disorders, liver and renal dysfunction, and sterility. Increasing evidence suggests that oxidative stress plays a critical role in Dyslipidemia Research Paper obesity to these associated complications 1 — 3. Recent studies have proposed that the causes of oxidative stress in obesity include hyperleptinemia, hyperglycemia, insufficient antioxidant capacity, increased free radical generation, mitochondrial dysfunction, and chronic inflammation 45. Accumulating evidence also shows that the quality of diet has demonstrated a negative shift toward consumption of high-energy foods, while intake of nutrient-rich foods such as fruits and vegetables has decreased Reseach7.
Such low-quality diets have been linked to a higher risk of obesity 8 consequently, dietary modification is frequently recommended as the main approach in prevention and treatment of obesity 9 Many studies Dyslipidemia Research Paper also indicated that natural products such as phytochemicals in fruits and vegetables can be vital modulators of the risks accompanying obesity. Mangosteen Garcinia mangostana L. Mangosteen has been used in various traditional remedies to treat fever, diarrhea, and to promote wound healing. Recently, it has been used as a chief constituent in health supplements for weight loss and for supporting overall health 11due to its well-known anti-oxidative and anti-inglammatory medicinal properties 12 — Additionally, mangosteen pericarp contains several phenolic compounds, such as benzoic acid, tyrosol, and protocatechuic acid, which are known to have anti-oxidative and anti-inflammatory effects.
Interestingly, various studies have revealed that spices such as curcumin may show efficacy in controlling weight gain or reducing obesity. Curcumin is a bioactive polyphenol component found in turmeric rhizomes Clinical effects of curcumin in reducing weight and body mass index BMI have not Dyslipidemia Research Paper thoroughly assessed, and the results of many studies are unreliable and contradictory. Multiple studies have reported that a bioavailable form of curcumin resulted in improved weight management in obese humans and experimental animals 16 High-energy diets have been utilized to induce obesity and related metabolic disorders in rodent models; however, dietary mediation has not been absolutely standardized Usually, these diets comprise a simple exchange of carbohydrate-derived calories with fat-derived calories and are compared with a standard chow diet SCD as a control.
In this study, we sought to determine the potency of Garcinia mangostana pericarp extract and curcumin either independently or synergistically in modulating biochemical here of oxidative stress, hyperlipidemia, and hyperglycemia in a high-fat diet-induced rodent Dyslipidemia Research Paper of obesity. While the BMI in obese controls Group 5 reached 0.]
Bravo, this brilliant idea is necessary just by the way
In my opinion you commit an error. I can defend the position. Write to me in PM, we will communicate.
In it something is also idea excellent, agree with you.
I think, that you are mistaken. Write to me in PM, we will discuss.
What interesting question