Diabetes Mellium Case Study Video
Diabetes mellitus (type 1, type 2) \u0026 diabetic ketoacidosis (DKA) Diabetes Mellium Case Study
Introduction Diabetes mellitus DMa very complex and heterogeneous chronic disease, is associated with chronic complications generated by alteration of the endothelium at all arterial vascular territory levels. The micro-and macro-vascular complications affect the entire body; Diabetes Mellium Case Study pathogenic mechanisms are intricate and involve multiple pathways and risk factors. Cardiovascular disease is considered a major cause of morbidity and mortality among people with diabetes, with a significantly increased prevalence compare with people without diabetes. The risk increases with the level of glycaemia, the duration of diabetes and the number of risk factors.
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People with Casee have much earlier and more extensive process of accelerated atherosclerosis, more vulnerable and larger volume atherosclerotic plaques and coronary artery lumen with a smaller diameter, compared to people without DM. The pathogenic complex is influenced by genetic factors, age, personal history and a pro-risk lifestyle unhealthy eating, sedentary lifestyle, smoking, sleep disorders, psychosocial stress and depression [ 1 ].
The macrovascular complications mainly refer to the atherosclerotic cardiovascular disease, represented by coronary artery disease acute and chronic coronary syndrome CADchronic Diabetes Mellium Case Study artery disease PAD and cerebrovascular disease CBV. A particular complication is heart failure HF. The pathogenic mechanisms of micro-and macro-angiopathy are extremely complex, with multiple interactions at the molecular-cellular and vascular-organic level.
Although all complications declined in the last decades, the most significant decreases in diabetes-related complications occurred for heart attack and Diabetes Mellium Case Study, especially for people aged 75 years and older. The CVD risk and mortality rate has declined in both the general population [ 2 ] and the people with diabetes [ 3 ]. However, diabetes, mainly T2DM, continues to be an important generator of cardiovascular disease. As the number of patients with diabetes is predicted to increase, reaching million in [ 4 ], it is expected that the number of people with Cade will also increase.
Thus, these major diabetes complications Diabetes Mellium Case Study to place a heavy burden on Diabetes Mellium Case Study care systems. Cardiovascular risk 2. Studies of cardiovascular disease epidemiology Casr its causes began in the s, with Framingham Heart Study being one of the first. Subsequently, Framingham study and other epidemiological studies, have identified other risk factors, including obesity, diabetes, dyslipidemia, sedentary lifestyle. Thus diabetes is associated with a 2- to 3-fold http://pinsoftek.com/wp-content/custom/stamps/lidl-case-study-solution.php in the risk of developing CVD and glucose intolerance with a 1. In addition to hyperglycemia, diabetes, mainly T2DM, is accompanied by other cardiovascular risk factors, within the metabolic syndrome: insulin resistance, abdominal obesity, atherogenic dyslipidemia hypertriglyceridemia, low HDL-C High-density lipoprotein cholesterolLDL-C low density lipoprotein cholesterol particlesremnant lipoproteins, postprandial hyperlipidemiahigh blood pressure, prothrombotic, proinflammatory and oxidative stress state, microalbuminuria, non-alcoholic fatty liver disease [ 8 ].
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High blood Diabetes Mellium Case Study increases 2—4 times the risk of CVD, kidney and death, atherogenic dyslipidemia induces a residual CVR, even under statin treatment and LDL-C Casee and abdominal obesity, as a component of metabolic syndrome, significantly increases the risk of coronary heart disease, stroke and death [ 91011 ].
This risk increases with the increase of fasting glycaemia since the stages of prediabetes. Epidemiological studies have Stkdy that the excess relative Diabetes Mellium Case Study of vascular events is more significant in women, at younger ages, in long-standing DM and in the presence of microvascular complications, mainly renal disease or proteinuria [ 12 ]. Early-onset at 1—10 years of age was correlated with an HR hazard ratio of 7. Progress of T1DM between 1 and 10 years of age resulted in a loss of These results confirm the loss of years of life in both populations, which is more severe in the younger patients and in young-onset female individuals with T2DM, highlighting the need for early and intensive risk-factor interventions in these clusters of Csse.
T2DM is reputed as an independent risk factor for the development of HF. For practice, CVR assessment scores which can be applied in diabetes are beneficial. The first is this web page result of the United Kingdom Prospective Diabetes Study UKPDSin which, in people newly diagnosed with T2DM, the effect of intensive treatment on the evolution of chronic complications compared to conventional treatment was followed. It refers to patients with T2DM without CVD, is based on the usual parameters and estimates the risk of major CV events at four years, the risk of renal events at five years and the risk of major vascular disease at ten years www.]
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