The Influence Of Dual Identity - something is
Advanced Search In the developing spinal cord, motor neurons acquire columnar subtype identities that can be recognized by distinct profiles of homeodomain transcription factor expression. The mechanisms that direct the differentiation of motor neuron columnar subtype from an apparently uniform group of motor neuron progenitors remain poorly defined. In the chick embryo,the Mnx class homeodomain protein MNR2 is expressed selectively by motor neuron progenitors, and has been implicated in the specification of motor neuron fate. We show here that MNR2 expression persists in postmitotic motor neurons that populate the median motor column MMC , whereas its expression is rapidly extinguished from lateral motor column LMC neurons and from preganglionic autonomic neurons of the Column of Terni CT. Finally, MNR2 appears to regulate motor neuron identity by acting as a transcriptional repressor, providing further evidence for the key role of transcriptional repression in motor neuron specification. In the vertebrate central nervous system CNS , the specification of neuronal identity is initiated by inductive factors that are secreted from local cell groups Jessell and Melton, One role of such factors is to impose a specific profile of transcription factor expression on neural progenitor cells, thus restricting their developmental potential and directing the production of specific classes of neuron Goridis and Brunet,Agree: The Influence Of Dual Identity
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