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Advanced Search The developmental fate of cells in the distal region distal cap of the epiblast was analysed by fate mapping studies. The displacement and differentiation of cells labelled in situ with carbocyanine dyes and lacZ-expressing cells grafted to the distal cap were studied over a hour period of in vitro development. The distal cap epiblast differentiates predominantly into neurectodermal cells. Cells at the anterior site of the distal cap colonise the fore-, mid- and hindbrain and contribute to non-neural ectoderm cells of the amnion and craniofacial surface ectoderm. Those cells in the most distal region of the epiblast contribute to all three brain compartments as well as the spinal cord and the posterior neuropore. Cells at the posterior site of the distal cap are mainly localised to the caudal parts of the neural tube. The Mouse Body
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The Mouse Who Got a New Body December 16, It may sound like something out a science fiction movie, but allogenic head and body reconstruction research is moving full speed ahead at Harbin Medical University in China. In the s and s, Dr. White was pioneering work The Mouse Body dealt specifically with the anatomical complications of such a transplant.
Where he failed was in immunotherapy. His animal bodies ultimately rejected the new head, initiating a microscopic battle on the foreign tissue. We have come a long way since then.
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The first successful hand transplant was conducted more than a decade ago. Livers, kidneys and other organs are routinely transplanted as well. Though we have not completely solved the immunotherapy issue, we have made great progress.
Enough progress that Dr. Xiaoping Ren wants to revisit the head transplant idea. His study, Head Transplant in Mouse Model, is only the first step. In this study he used mice as his guinea pigs, so to speak, in an effort to develop a model where their brains would survive the procedure.
Brain ischemia results in the death of brain tissue, which would render any head transplant unsuccessful. The trial was a success.]
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