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In Vitro Meat: A Case Study Dr. Solers Leadership Style Essay
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In Vitro Meat: A Case Study

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Aqueous extracts of E. The hepatic steatosis effect of E. External performance of the obesity-alleviation effect was monitored by measuring body and food weight. In addition, the metabolomics analysis of the E. The presence and spatial distribution patterns of differential molecules were further evaluated through desorption electrospray ionization-mass spectrometry imaging.

Figure 1. Considerations and correlating burdens of proof to be considered for microphysiological systems design and approaches. The complexity of the biological model will be determined by the end-user needs as well as the most common available infrastructure to the intended end-user. Academia is the most receptive to a variety of designs, which affords opportunities for novel discoveries and opens new research avenues.

Abbreviations

The Stdy and biotechnology industries have less degrees of freedom, aiming for function over novelty, requiring design considerations for companion technologies or adherence to minimum requirement regulatory parameters. The complexity of a biological model will be dictated by biomechanical e.

ADMET — absorption, distribution, metabolism, excretion and toxicology. Compiled from 3 — 542 — Could it be an easier route to provide a service delivery function to the end-user once the model is established?

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The academic end-user Sudy be grant dependent with a focus on publication frequency and impact seeking novelty, providing degrees of freedom for creativity in model complexity with inclusion of various companion technologies. Biotechnology and CRO companies present with research or service delivery specialization, where model design and allowances for companion technologies are dictated by the contract giver e.

Pharmaceutical and some biotechnology companies may require HT and HC screening solutions where biological complexity should provide equal or better results than current in vitro 2D models but allow for facile integration into existing infrastructure and automated workflows. Examples of this will be discussed with reference to Figure 2also considering Figure 1 as well as Table 1.

In Vitro Meat: A Case Study

Figure 2. A liver biopsy sample has many applications beyond diagnostics and pathology.

Introduction

The biopsy tissue can be prepared as precision cut slices PCS used in direct ex vivo histoculture, rodent xenografted or used for isolating specific cell types which can be used in multiple tissue engineering approaches. Applications of these approaches can range from preclinical research to translational precision medicine.

In Vitro Meat: A Case Study

Example 1: A pharmaceutical technologist needs to identify 10 most active lead candidate compounds from a 10,compound library for minimal liver toxicity. A two-dimensional monoculture 2DMC in vitro model has the minimum required physiological complexity based on DDP recommendations with regulatory approval, where the methodology for HT-HC screening is already optimized to be cost- and time-efficient in an automated workflow. A MPS solution must demonstrate obvious advantages compared to the biological model, also demonstrating compatibility with the available and optimized infrastructure.

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The ideal model will be based on link and organoids SO technology with added physiological complexity in a 3D environment, such as using extracellular matrix ECM -mimics and hydrogels, remaining compatible with HT-HC methodology 65 — Example 2: A liver biopsy is taken from a patient to diagnose a liver pathology Figure 2. Apart from the histology-based diagnosis, some tissue can be used for various applications for the researcher from pure academic, preclinical or translation applications. The biopsy tissue can xenografted 8081 or used to make patient specific-SO 6673with the former allowing for the generation of SO as well. Alternately, the biopsy can be used as a precision cut slice or cubic biopsy samples 7983 or preserved in a biobank 76 The patient derived cells can be isolated into subtypes for SO generation or mixed into a scaffold for cellular self-assembly.

In Vitro Meat: A Case Study inclusion of ECM-mimics and hydrogels, dynamic or static culture conditions and desired bio chemical stimulus will be determined by the needs of the end-user.

In Vitro Meat: A Case Study

This type of approach where creativity is encouraged is typical for research institutes and well-funded researchers, where academic freedom allows for creating diverse solutions to advance state-of-the-art for models intended to be used for toxicology, disease modelling and precision medicine.]

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