Lactate Lab Report Video
What Lactate is \u0026 What it ACTUALLY does: 5 Min Phys Lactate Lab ReportGlioma cells expressing deEGFR contain an intracellular pool of receptor with high levels of mannose glycosylation, which is consistent with delayed processing. We now show that this delay occurs in the Golgi complex. Low levels of deEGFR were also seen within the mitochondria.
Chemical Aspects of Life and Spit Lab Formal Report
Src activation dramatically increased the amount of mitochondrial deEGFR, whereas its pharmacological inhibition caused a significant Lactate Lab Report. The deEGFR Lacate mutant failed to show mitochondrial localisation, even when co-expressed with constitutive active Src. Low levels of glucose enhanced mitochondrial localisation of deEGFR, and glioma cells expressing the receptor showed increased survival and proliferation under these conditions.
Consistent with this, deEGFR reduced glucose dependency Lactate Lab Report stimulating mitochondrial oxidative metabolism. Thus, the mitochondrial localisation of deEGFR contributes to its tumorigenicity and might help to explain its resistance to some EGFR-targeted therapeutics. This mutant consists of an in-frame deletion spanning exons 2—7 of the coding sequence, resulting in the deletion of amino acid residues from the extracellular domain and the insertion of a novel glycine residue at the junction site Humphrey et al. As Lactate Lab Report result of this truncation, the deEGFR is unable to bind any known ligand. Despite this, deEGFR displays low level constitutive kinase activity that leads to the prolonged activation of downstream signalling pathways Chakravarti et al.
The enhanced tumorgenicity mediated by deEGFR-expressing cells in part results from direct association or crosstalk between this truncated receptor and other cell-surface receptors such as the wtEGFR and Met Huang et al.
Lab Report on Measuring the Rate of Conversion of Hydrogen Peroxide using Enzyme Catalysis
There are two reports from the same group showing that wtEGFR can translocate to the mitochondria Boerner et al. The authors hypothesised a mitochondrial localisation after showing that a phosphorylated, but not unphosphorylated, peptide containing Y bound the mitochondrial protein CoxII.
They then showed that the wtEGFR could translocate to the mitochondria following ligand stimulation in the presence of Src, where it can phosphorylate CoxII.]
One thought on “Lactate Lab Report”