Simple Condensation Reaction Report Video
Simple Condensation Reaction Report
Pictet-Spengler, canthinone, Simaroubaceae Abstract The family of Simaroubaceae is known to contain quassinoids and canthinones, secondary metabolites that have been reported to possess numerous biological activities such as anticancer.
A biomimetic total synthesis of canthinone using Pictet-Spengler condensation according to the procedure by Czerwinski et al. The aim of this study was to determine the viability of this reaction for structural modification.
Introduction
In this report, influential factors of carboxyl mediated Pictet-Spengler condensation reaction would be discussed. References Pictet, A. Berichte der Deutsch Chemistry Gesellschaft. Haynes, H. Alkaloids of the Australian Rutaceae: Pentaceras autralis Hook. I Isolation of the Alkaloids and Identification of canthinone.
Ohmoto T. Canthinone alkaloids. Brossi, Ed. Academic Press Inc. National Center for Biotechnology Information. Koike, K. Natural Medicine. Arias, J. Biodegradable Polymeric Nanoformulation Based on the Antiprotozoal canthinone. Journal of Nanoparticle Research.
Chiou, W. Journal of Sexual Medicine. Fan, H. Jiao, W. Chemical Pharmaceutical Bulletin Tokyo. Ferreira, M. Effects of canthinone Alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected Mice. Journal of Ethnopharmacology.
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Fukamiya, N. Antitumor Agents, Cytotoxic Antileukemic Alkaloids from Brucea antidysenterica. Journal of Natural Products. Journal of Ehnopharmacology. Kuo, P. Cytotoxic and Antimalarial Constituents from the Roots of Eurycoma longifolia. Bioorganic Medicinal Chemistry.
Czerwinski, K. An Improved Synthesis of canthinone. Synthetic Communication.]
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