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However, the prognostic relevance of polymorphisms in GST omega genes was not found in our cohort of PC patients. Introduction Prostate cancer PC is second to lung cancer in terms of the number of cancer deaths among men in the United States and European Union, representing the sixth leading cause of all cancer deaths worldwide Bray et al. Specific characteristics of the majority of PCs, including the slow growth rate and low metastatic potential, imply the significance of recognition of high-risk patients who are candidates for aggressive therapy at the time of the first diagnosis in comparison to those who can be managed conservatively through active surveillance Mottet et al. Representing the superfamily of detoxifying enzymes with overlapping biotransformational capacities toward xenobiotics, as well as endogenous reactive oxygen species Wu and Dong, , the role of glutathione transferases GSTs has been extensively studied in the development and progression of different cancers Pljesa-Ercegovac et al. The most established epigenetic biomarker in PC is the silencing of glutathione transferase P1 GSTP1 being recognized as a hallmark of prostate carcinogenesis Martignano et al. Besides, the protective effect of GSTP1 haplotype associated with more efficient protection against carcinogenic compounds in PC susceptibility has been suggested recently Santric et al. Apart from its catalytic detoxifying role, GSTP1 is involved in the process of glutathionylation, as well as regulation of redox-dependent apoptotic signaling Pljesa-Ercegovac et al. Regarding glutathionylation, it represents the posttranslational modification of protein thiol groups by the formation of mixed disulfides with glutathione. Glutathione Case StudyGlutathione Case Study Video
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In Vivo Pharmacokinetic and Antioxidant Activity of PWPC-GSH Whey protein has been widely studied as an effective means of nutrient delivery due to its resistance to digestion by pepsin [ 38 ], its non-toxic nature, widely available sources and broad biocompatibility. These results were consistent with previous studies that the bioavailability of quercetin and vitamin D were improved through whey protein encapsulating [ 4142 ].
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Pharmacokinetic parameters were calculated as shown in inset of Figure 3 A. Compared with free GSH maximum concentration Cmax of 7. The 2.
GSH in Glutathione Case Study pure form on its own. Whey protein also appears to possess a protective effect on GSH as a carrier during absorption into intestinal tract which may due to the resistance to digestion by pepsin.
In addition to delivery of the GSH itself, the whey protein supplementation may have also contributed to the increase in GSH levels in vivo [ 43 Stuey, 44 ] by virtue of the abundance of cysteine residue inherent to whey protein, which has the capability to promote biosynthesis of GSH as a rate-limiting amino acid [ 45 ].
The lower time to maximum concentration Tmax 1 h occurred in the PWPC-GSH group in comparison with that in free GSH 2 hindicating less time was required to reach the maximum concentration after administration. Total antioxidative capacity of samples at different time points was measured using an assay kit and the results are shown in Figure 3 B. The second reason may be due to the antioxidant Glutathione Case Study of whey protein [ 1947 ] [ 48 ]. As shown in Figure 3 B, the plasma antioxidant capacity of mice after gavage with PWPC was also slightly improved to a degree that may or may not be consistent with an Glutathione Case Study effect.
Clinical Observations, Body Weight, and Food Consumption During the experiment, there was no observed adverse effects in the experimental groups compared with the control groups.
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Body weight of all rats increased gradually as the treatment period progressed Figure 4 A. However, the body weight changes were observed only in male groups and there was no does-dependent effect, so it was interpreted as having no toxicological significance. During the study, the weight of rats in the experimental groups was comparable to that of rats in the Stufy groups. Results for food consumption of rats for 28 days are shown Glutathione Case Study Figure 4 B. There was no PWPC-GSH-related toxicity effect observed in experimental groups although there was some significant difference between experimental groups and control groups at some time points.
In female rats, there was a statistically significant difference in food consumption of the 0.]
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