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Malaria-endemic countries eastern hemisphere Malaria-endemic countries western hemisphere Genes may be under strong selection in response to local diseases. For example, people who are duffy negative tend to have higher resistance to malaria. Most Africans are duffy negative and most non-Africans are duffy positive due to endemic transmission of malaria in Africa. Many theories about the origin of the cystic fibrosis have suggested that it provides a heterozygote advantage by giving resistance to diseases earlier common in Europe. In earlier research, a common theory was the " common disease-common variant " model. It argues that for common illnesses, the genetic contribution comes from the additive or multiplicative effects of gene variants that each one is common in the population. Physical Distribution Case Study Physical Distribution Case Study

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Physical Distribution Case Study

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Physical Distribution Case Study

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