Bartter Syndrome Case Study.
Prenatal diagnosis of Bartter syndrome: amniotic fluid aldosterone.
1. Introduction
ABSTRACT: Bartter syndrome is a severe inherited tubulopathy characterized at birth by salt wasting, severe polyuria, dehydration, growth retardation and secondary hyperaldosteronism. Prenatally, the disease is usually discovered following onset of severe polyhydramnios. We studied amniotic fluid aldosterone concentration in cases of Bartter syndrome and in control groups.
Amniotic fluid aldosterone was assayed by radioimmunoassay. We undertook a Cass case-control study based on 36 cases of postnatally diagnosed Bartter syndrome and controls matched for gestational age. Amniotic fluid aldosterone was compared between the three groups. In conclusion, amniotic fluid aldosterone assay cannot be used for prenatal diagnosis of Bartter syndrome.]
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