Monoamine Theory - there
Chemical Imbalance Theory Throughout the checkered history of psychotropic drugs, one theory has been perpetuated: Many people believe that the risks still outweigh the benefits of these psychoactive drugs , at least when it comes to depression. Joseph Schildkraut, a Harvard psychiatrist. According to one of his collaborators, Dr. Alan I. The Reality Behind the Chemical Imbalance Theory Myth The problem with the chemical imbalance theory is that it has never been proven — in fact, many studies on the subject have come to the exact opposite conclusion. While formulated on the basis that SSRIs selective serotonin reuptake inhibitors had mild effectiveness on relieving depression , Jeffrey Lacasse, Ph. Two major points Leo and Lacasse make in this breakthrough piece are that: Administering high dose L-tryptophan an amino acid to raise serotonin does not relieve depression. High doses of this are considered possibly unsafe when taken in supplement form, although small doses that do not raise serotonin levels significantly are thought to be safe. Monoamine Theory.
Introduction
References What Causes Depression? There are various competing and sometimes Thsory Monoamine Theory that aim to explain mood disorders such as depression. The biological model, and the one that most closely guides the kinds of medication supplied for depression, is that psychological problems are caused by one or more problems in the brain.
In depression the focus of attention is generally around genetic predisposition, hormones and neurology. In the case of neurology, too little of one or more neurotransmitters at the synapse is thought to affect mood, which is the basis of the monoamine hypothesis of depression.
Despite this, the actual biological theory is based around three neurotransmitters known as the monoamine group; namely serotonin, dopamine and norepinephrine. The Monoamine Hypothesis The monoamine hypothesis of depression states that a depletion Monoamine Theory neurotransmitters, known as monoamines, within the brain leads to depression.
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This depletion may be related to a lack of neurotransmitters or some other fault. For example, people with major depressive disorder may also have fewer monoamine nerve receptors, or possibly less sensitive receptors than people without depression.
Theorg effect would be the same as a low level of neurotransmitters. As much as depression may be caused Monoamlne an undersupply of neurotransmitters other mood disorders, Monoamine Theory example mania, are presumed to be caused by an oversupply of neurotransmitters. Serotonin and norepinephrine are examples of monoamines. Within the body another monoamine called monoamine oxidase has the effect of breaking down both serotonin and norepinephrine. Therefore, so the theory goes, by blocking the effect of the monoamine oxidase, the number of monoamines in the brain increases and symptoms of depression are relieved. A class of drugs known as monoamine oxidase inhibitors MAOIof which phenelzine Nardil is one example, have this effect. The Development of Antidepressant Medications The monoamine theory actually developed from something of a happy accident.
During the testing of a drug called imipramine, originally aimed at relieving the symptoms of tuberculosis, and subsequently reducing psychotic symptoms learn more here schizophrenia, researchers noticed a marked antidepressant effect. By the s, two classes of Monoamine Theory were introduced, the tricyclic antidepressants so called because of their chemical structure Monoamine Theory MAOIs.]
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