Gum Disease Case Study
Medical Xpress 19 Apr,Researchers have found a higher likelihood of evidence for amyloid beta in the CSF in older individuals who harbor harmful bacteria in the gums.
In a study involving 48 healthy, cognitively normal adults aged 65 and older it was seen that individuals with more harmful than healthy bacteria in the gums have reduced CSF amyloid levels. Researchers believe that healthy bacteria may be protective against Alzheimer's as they help maintain bacterial balance and decrease Caae. However, this imbalance in oral bacteria was not associated with another Alzheimer's biomarker called tau. Periodontal disease—which affects 70 percent of adults 65 Gum Disease Case Study older, according to CDC estimates—is characterized by chronic and systemic inflammation, with pockets between the teeth and gums enlarging and harboring bacteria.
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We found that having evidence for brain amyloid was associated with increased harmful and decreased beneficial bacteria. The present study adds support to the understanding that proinflammatory diseases disrupt the clearance of amyloid from Diseasd brain, as retention of amyloid in the brain can be estimated from CSF levels," said the study's senior author Mony J. Participants underwent oral examinations to collect bacterial samples from under the gumline, and lumbar puncture was used to obtain CSF in order to determine the levels of amyloid beta and tau. Gum Disease Case Study estimate the brain's expression of Alzheimer's proteins, the researchers looked for lower levels of amyloid beta which translate to higher brain amyloid levels and higher levels of tau which reflect higher brain tangle accumulations in Diseade CSF. Analyzing the bacterial DNA of the samples taken from beneath the gum line under the guidance of NYU College of Dentistry microbiologist Deepak Saxena, PhD, the researchers quantified bacteria known to be harmful to oral health e.
Prevotella, Porphyromonas, Fretibacterium and pro-oral health bacteria e. Corynebacterium, Actinomyces, Capnocytophaga.
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The results showed that individuals with an imbalance in bacteria, with a ratio favoring harmful to healthy bacteria, were more likely to have the Alzheimer's signature of reduced CSF amyloid levels. The researchers hypothesize that because high levels of healthy bacteria help maintain Stufy balance and decrease inflammation, they may be protective against Alzheimer's.
The researchers plan to conduct a longitudinal study and a clinical trial to test if improving gum health—through "deep cleanings" to remove deposits of plaque and tartar from under the gumline—can modify brain amyloid and prevent Alzheimer's disease. Also Read.]
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