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Homer William Smith — was best known for his work as a renal physiologist. His extensive research on the mammalian kidney greatly enhanced our understanding of the functional properties of the glomeruli, tubules and renal vascular bed, and his examination and comprehension of functional alterations in renal disease garnered him a great deal of respect from clinical physicians and physiologists alike Pitts, Dabbling should be a term used lightly as Smith's early experiments in comparative physiology built the foundation for our current knowledge of nitrogen excretion in fish. In his seminal paper in the Journal of Biological Chemistry, Smith became the first researcher to report that the gills are the major site of nitrogen excretion in freshwater fish Smith, In vertebrates, amino acids cannot be stored in the tissues without detrimental effects to the physiology of an animal. Therefore, ammonia must be either eliminated or modified to urea or uric acid to avoid adverse effects on normal physiological function and homeostasis. Although the precise pathologies of ammonia toxicity were not elucidated until over 50 years later reviewed by Ip et al. In contrast, the limited literature available on fish at the time indicated that teleosts excreted only small amounts of nitrogenous compounds in their urine Denis, ; Grollman, Smith was intrigued that the main urinary constituent in these studies was reportedly creatine and all other nitrogenous products were unusually low. Therefore, Smith hypothesized that the most probable route for the loss of nitrogenous waste i. Nitrogen Research PaperNitrogen Literature Reviews Samples For Students 5 samples of this type Do you feel the need to examine some previously written Literature Reviews on Nitrogen before you begin writing an own piece?
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